Gene Variant Detail

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Gene HRAS
Variant A66E
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions HRAS A66E does not lie within any known functional domains of the Hras protein (UniProt.org). A66E results in intrinsic and GAP-stimulated GTPase activity comparable to wild-type Hras in in vitro assays (PMID: 1730690), and therefore, is predicted to have no effect on Hras protein function.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS A66E

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Transcript NM_005343.4
gDNA chr11:g.533858_533859delCCinsAG
cDNA c.197_198delCCinsAG
Protein p.A66E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533858_533859delCCinsAG c.197_198delCCinsAG p.A66E RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533858_533859delCCinsAG c.197_198delCCinsAG p.A66E RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533858_533859delCCinsAG c.197_198delCCinsAG p.A66E RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533858_533859delCCinsAG c.197_198delCCinsAG p.A66E RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533858_533859delCCinsAG c.197_198delCCinsAG p.A66E RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533858_533859delCCinsAG c.197_198delCCinsAG p.A66E RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References