Gene Variant Detail

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Gene TP53
Variant S378P
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions TP53 S378P lies within the region of the Tp53 protein involved in repression of DNA binding and interaction with CARM1 (UniProt.org). S378P results in colony growth (PMID: 33257846), p21 binding, regulation of target promoters, and STAT4 mRNA expression similar to wild-type Tp53 in culture (PMID: 24076587), and therefore, is predicted to have no effect on Tp53 protein function.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon11 TP53 S378P

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Transcript NM_000546.6
gDNA chr17:g.7669659A>G
cDNA c.1132T>C
Protein p.S378P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000546.6 chr17:g.7669659A>G c.1132T>C p.S378P RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7669659A>G c.1132T>C p.S378P RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7669659A>G c.1132T>C p.S378P RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7669659A>G c.1132T>C p.S378P RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7669659A>G c.1132T>C p.S378P RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7669659A>G c.1132T>C p.S378P RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7669659A>G c.1132T>C p.S378P RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References