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Gene FGFR2 PHGDH
Variant FGFR2 - PHGDH
Impact List fusion
Protein Effect gain of function
Gene Variant Descriptions FGFR2-PHGDH results from the fusion of FGFR2 and PHGDH, which leads constitutive activation of FGFR2 signaling in cell culture and results in tumor formation in a mouse model (PMID: 33926920). FGFR2-PHGDH has been identified in intrahepatic cholangiocarcinoma (PMID: 33926920).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 rearrange FGFR2 fusion FGFR2 - PHGDH

FGFR2 mutant FGFR2 act mut FGFR2 - PHGDH

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 - PHGDH intrahepatic cholangiocarcinoma predicted - sensitive Debio 1347 Preclinical - Cell culture Actionable In a preclinical study, Debio 1347 inhibited growth of an intrahepatic cholangiocarcinoma cell line expressing FGFR2-PHGDH in culture (PMID: 33926920). 33926920
FGFR2 - PHGDH intrahepatic cholangiocarcinoma predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, Lytgobi (futibatinib) inhibited growth of an intrahepatic cholangiocarcinoma cell line expressing FGFR2-PHGDH in culture PMID: 33926920). 33926920
FGFR2 - PHGDH cholangiocarcinoma predicted - sensitive KIN-3248 Preclinical Actionable In a preclinical study, KIN-3248 treatment was active in a cholangiocarcinoma cell line harboring FGFR2-PHGDH (J Clin Oncol 40, 2022 (suppl 4; abstr 461). detail...