Gene Variant Detail

Gene CTNNB1
Variant Y30_S33del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions CTNNB1 Y30_S33del results in the deletion of four amino acids in the ubiquitination recognition motif of the Ctnnb1 protein from amino acids 30 to 33 (PMID: 15064718). Y30_S33del has been identified in sequencing studies (PMID: 18467159), but has not been biochemically characterized and therefore, its effect on Ctnnb1 protein function is unknown (PubMed, Feb 2019).
Associated Drug Resistance

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Transcript NM_001098210
gDNA chr3:g.41224600_41224611del12
cDNA c.88_99del12
Protein p.Y30_S33delYLDS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001098210 chr3:g.41224600_41224611del12 c.88_99del12 p.Y30_S33delYLDS RefSeq GRCh38/hg38
XM_006712984 chr3:g.41224621_41224632del12 c.88_99del12 p.S30_T33delSGAT RefSeq GRCh38/hg38
NM_001904 chr3:g.41224600_41224611del12 c.88_99del12 p.Y30_S33delYLDS RefSeq GRCh38/hg38
NM_001098209 chr3:g.41224600_41224611del12 c.88_99del12 p.Y30_S33delYLDS RefSeq GRCh38/hg38
XM_006712985 chr3:g.41224600_41224611del12 c.88_99del12 p.Y30_S33delYLDS RefSeq GRCh38/hg38
XM_017005738 chr3:g.41224600_41224611del12 c.88_99del12 p.Y30_S33delYLDS RefSeq GRCh38/hg38
XM_005264886 chr3:g.41224600_41224611del12 c.88_99del12 p.Y30_S33delYLDS RefSeq GRCh38/hg38
XM_006712983 chr3:g.41224621_41224632del12 c.88_99del12 p.S30_T33delSGAT RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
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Molecular Profile Protein Effect Treatment Approaches
CTNNB1 Y30_S33del unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References