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Gene | BRAF |
Variant | class 1 |
Impact List | unknown |
Protein Effect | gain of function |
Gene Variant Descriptions | BRAF Class 1 variants are BRAF variants that activate BRAF and downstream signaling in a dimer-independent, RAS-independent manner (PMID: 28783719, PMID: 26343582). |
Associated Drug Resistance | |
Category Variants Paths |
BRAF mutant BRAF act mut BRAF class 1 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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