Gene Variant Detail

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Gene FLT3
Variant F594_W603dup
Impact List duplication
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 F594_W603dup indicates the insertion of eight duplicate amino acids, aspartic acid (D)-593 through tryptophan (W)-603, in the juxtamembrane domain of the Flt3 protein (PMID: 14759363). FLT3 F594_W603dup has not been biochemically characterized, but can be predicted to lead to activation of Flt3 based on the effects of other Flt3 internal tandem duplication (ITD) mutations (PMID: 12970773, PMID: 9737679, PMID: 11090077).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 F594_W603dup

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 F594_W603dup

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Transcript NM_004119
gDNA chr13:g.28034112_28034113insCTTAAGGTCATACTCATACTCCCTAAACCA
cDNA c.1809_1810insTTTAGGGAGTATGAGTATGACCTTAAGTGG
Protein p.F594_W603dup
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28034112_28034113insCTTAAGGTCATACTCATACTCCCTAAACCA c.1809_1810insTTTAGGGAGTATGAGTATGACCTTAAGTGG p.F594_W603dup RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 F594_W603dup acute myeloid leukemia predicted - sensitive Gilteritinib Case Reports/Case Series Actionable In a clinical study, Xospata (gilteritinib) treatment led to decreased disease burden (<10%) in an acute myeloid leukemia patient harboring FLT3 F594_W603dup (PMID: 33563661; NCT02670525). 33563661