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Gene PTEN
Variant L152P
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions PTEN L152P lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). L152P is associated with decreased Pten expression and increased Akt phosphorylation in cultured cells (PMID: 30289966), and results in reduced phosphatase activity in a yeast assay (PMID: 29706350).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN L152P

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Transcript NM_000314.8
gDNA chr10:g.87933214T>C
cDNA c.455T>C
Protein p.L152P
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87933214T>C c.455T>C p.L152P RefSeq GRCh38/hg38
NM_000314 chr10:g.87933214T>C c.455T>C p.L152P RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87933214T>C c.455T>C p.L152P RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
PTEN L152P PTEN neg salivary gland carcinoma resistant AZD8186 Preclinical - Cell culture Actionable In a preclinical study, salivary ductal carcinoma cells harboring PTEN L152P and loss of Pten protein expression were resistant to AZD8186-induced inhibition of Akt phosphorylation and proliferation in culture (PMID: 30289966). 30289966
PTEN L152P PTEN neg salivary gland carcinoma resistant GSK2636771 Preclinical - Cell culture Actionable In a preclinical study, salivary ductal carcinoma cells harboring PTEN L152P and loss of Pten protein expression were resistant to GSK2636771-induced inhibition of proliferation in culture (PMID: 30289966). 30289966
PTEN L152P PTEN neg salivary gland carcinoma resistant Alpelisib Preclinical - Cell culture Actionable In a preclinical study, salivary ductal carcinoma cells harboring PTEN L152P and loss of Pten protein expression were resistant to Piqray (Alpelisib)-induced inhibition of Akt phosphorylation and proliferation in culture (PMID: 30289966). 30289966
PTEN L152P PTEN neg salivary gland carcinoma sensitive Alpelisib + AZD8186 Preclinical - Cell culture Actionable In a preclinical study, combination of Piqray (Alpelisib) and AZD8186 inhibited Akt phosphorylation and proliferation of salivary ductal carcinoma cells harboring PTEN L152P and loss of Pten protein expression in culture (PMID: 30289966). 30289966
PTEN L152P PTEN neg salivary gland carcinoma sensitive Pictilisib Preclinical - Cell culture Actionable In a preclinical study, Pictilisib (GDC-0941) inhibited Akt phosphorylation and proliferation of salivary ductal carcinoma cells harboring PTEN L152P and loss of Pten protein expression in culture (PMID: 30289966). 30289966