Gene Variant Detail

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Gene BRAF
Variant R682W
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF R682W lies within the protein kinase domain of the Braf protein (UniProt.org). R682W has been demonstrated to confer resistance to Tarceva (erlotinib) in the context of EGFR exon 19 deletions in cultured cells (PMID: 27478040), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, Oct 2022).
Associated Drug Resistance Y
Category Variants Paths

BRAF mutant BRAF R682W

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Transcript NM_004333.5
gDNA chr7:g.140739895G>A
cDNA c.2044C>T
Protein p.R682W
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354609.1 chr7:g.140739895G>A c.2044C>T p.R682W RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140739895G>A c.2044C>T p.R682W RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References