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Gene FGFR3
Variant T311fs
Impact List frameshift
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR3 T311fs results in a change in the amino acid sequence of the Fgfr3 protein beginning at aa 311 of 806, likely resulting in premature truncation of the functional protein (UniProt.org). T311fs results in proliferation similar to wild-type Fgfr3 in a competition assay and transformation activity similar to wild-type Fgfr3 in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr3 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 T311fs

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Transcript NM_000142.5
gDNA chr4:g.(1802025_1803692)
cDNA c.(931_930)
Protein p.T311fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713873.2 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
XM_011513420.1 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
NM_001354810.2 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
NM_000142.4 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
NM_000142.5 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
XM_011513420.2 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.(1802025_1803692) c.(931_930) p.T311fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries