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Gene | KDR |
Variant | S1100F |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | KDR (VEGFR2) S1100F lies within the protein kinase domain of the Kdr (Vegfr2) protein (UniProt.org). S1100F results in decreased ligand-induced phosphorylation of Kdr (Vegfr2) and Mapk in cell culture (PMID: 28743916), but induces increased tumor growth in cell line xenografts (PMID: 29588308), and therefore, its effect on Kdr (Vegfr2) protein function is unknown. |
Associated Drug Resistance |
Transcript | NM_002253.3 |
gDNA | chr4:g.55089696G>A |
cDNA | c.3299C>T |
Protein | p.S1100F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002253 | chr4:g.55089696G>A | c.3299C>T | p.S1100F | RefSeq | GRCh38/hg38 |
NM_002253.3 | chr4:g.55089696G>A | c.3299C>T | p.S1100F | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
KDR S1100F | unknown |