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Gene | STK11 |
Variant | S31F |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | STK11 S31F does not lie within any known functional domains of the Stk11 protein (UniProt.org). S31F results in kinase activity similar to wild-type Stk11 in an in vitro assay and Stk11-dependent Tp53-mediated transcriptional activity similar to wild-type in a reporter assay (PMID: 34849607), and therefore, is predicted to have no effect on Stk11 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
STK11 mutant STK11 S31F |
Transcript | NM_000455.5 |
gDNA | chr19:g.1207005C>T |
cDNA | c.92C>T |
Protein | p.S31F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
XM_005259617.3 | chr19:g.1207005C>T | c.92C>T | p.S31F | RefSeq | GRCh38/hg38 |
NM_000455.5 | chr19:g.1207005C>T | c.92C>T | p.S31F | RefSeq | GRCh38/hg38 |
NM_001407255.1 | chr19:g.1207005C>T | c.92C>T | p.S31F | RefSeq | GRCh38/hg38 |
NM_000455.4 | chr19:g.1207005C>T | c.92C>T | p.S31F | RefSeq | GRCh38/hg38 |
XM_005259618.3 | chr19:g.1207005C>T | c.92C>T | p.S31F | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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