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Gene | STK11 |
Variant | A417S |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | STK11 A417S lies within the C-terminal domain of the Stk11 protein (PMID: 23612973). A417S results in kinase activity similar to wild-type Stk11 in an in vitro assay and Stk11-dependent Tp53-mediated transcriptional activity similar to wild-type in a reporter assay (PMID: 34849607), and therefore, is predicted to have no effect on Stk11 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
STK11 mutant STK11 A417S |
Transcript | NM_000455.5 |
gDNA | chr19:g.1226594G>T |
cDNA | c.1249G>T |
Protein | p.A417S |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000455.4 | chr19:g.1226594G>T | c.1249G>T | p.A417S | RefSeq | GRCh38/hg38 |
NM_000455.5 | chr19:g.1226594G>T | c.1249G>T | p.A417S | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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