Gene Variant Detail

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Gene PTEN
Variant Q171R
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions PTEN Q171R lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). Q171R confers a loss of function on Pten as demonstrated by altered cell morphology and cytoskeletal organization, decreased ability to suppress proliferation and migration, increased phosphorylation of Akt, and decreased apoptotic activity upon induction in cultured cells (PMID: 34943931).
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN Q171R

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Transcript NM_000314.6
gDNA chr10:g.87952137A>G
cDNA c.512A>G
Protein p.Q171R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87952137A>G c.512A>G p.Q171R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References