Gene Variant Detail

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Gene TP53
Variant N345Ifs*26
Impact List frameshift
Protein Effect loss of function
Gene Variant Descriptions TP53 N345Ifs*26 indicates a shift in the reading frame starting at amino acid 345 and terminating 26 residues downstream causing a premature truncation of the 393 amino acid Tp53 protein (UniProt.org). N345Ifs*26 results in oligomerization potential similar to wild-type Tp53, but results in increased Tp53 nuclear localization and protein stability, decreased DNA binding, and loss of Tp53 transactivation activity in cultured cells (PMID: 34045312).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon10 TP53 N345Ifs*26

TP53 mutant TP53 inact mut TP53 N345Ifs*26

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Transcript NM_000546.6
gDNA chr17:g.7670676_7670677insAT
cDNA c.1033_1034insTA
Protein p.N345Ifs*26
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407264.1 chr17:g.7670676_7670677insAT c.1033_1034insTA p.N345Ifs*26 RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7670676_7670677insAT c.1033_1034insTA p.N345Ifs*26 RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7670676_7670677insAT c.1033_1034insTA p.N345Ifs*26 RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7670676_7670677insAT c.1033_1034insTA p.N345Ifs*26 RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7670676_7670677insAT c.1033_1034insTA p.N345Ifs*26 RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7670676_7670677insAT c.1033_1034insTA p.N345Ifs*26 RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7670676_7670677insAT c.1033_1034insTA p.N345Ifs*26 RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References