Gene Variant Detail

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Gene ALK
Variant C928Lfs*20
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ALK C928Lfs*20 indicates a shift in the reading frame starting at amino acid 928 and terminating 20 residues downstream causing a premature truncation of the 1620 amino acid Alk protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), C928Lfs*20 is predicted to lead to a loss of Alk protein function.
Associated Drug Resistance
Category Variants Paths

ALK mutant ALK inact mut ALK C928Lfs*20

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Transcript NM_004304.5
gDNA chr2:g.29228917dupA
cDNA c.2782dupT
Protein p.C928Lfs*20
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004304.4 chr2:g.29228917dupA c.2782dupT p.C928Lfs*20 RefSeq GRCh38/hg38
NM_004304.5 chr2:g.29228917dupA c.2782dupT p.C928Lfs*20 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References