Gene Variant Detail

Gene APC
Variant G1120E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC G1120E lies within the beta-catenin binding region of the Apc protein (PMID: 14672538). G1120E inhibits beta-catenin-mediated transcription at a level similar to wild-type Apc in a yeast assay, but other aspects of Apc function were not evaluated (PMID: 14633595), and therefore, its effect on Apc protein function is unknown.
Associated Drug Resistance

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Transcript NM_000038
gDNA chr5:g.112838953G>A
cDNA c.3359G>A
Protein p.G1120E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001127510 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_000038 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
APC G1120E unknown
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References