Gene Variant Detail

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Gene APC
Variant G1120E
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions APC G1120E lies within the beta-catenin binding domain of the Apc protein (PMID: 14672538). G1120E inhibits beta-catenin mediated transcription at a level similar to wild-type Apc in a yeast assay (PMID: 14633595), and therefore, is predicted to have no effect on Apc protein function.
Associated Drug Resistance
Category Variants Paths

APC mutant APC G1120E

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Transcript NM_000038.6
gDNA chr5:g.112838953G>A
cDNA c.3359G>A
Protein p.G1120E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407455.1 chr5:g.112839202G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001127510 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001407456.1 chr5:g.112839202G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001354895.2 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001407457.1 chr5:g.112839202G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001407454.1 chr5:g.112839202G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_000038 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112838953G>A c.3359G>A p.G1120E RefSeq GRCh38/hg38

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Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
APC mutant desmoid tumor not applicable N/A Guideline Diagnostic APC mutations aid the diagnosis of desmoid tumor (NCCN.org). detail...
APC mutant small intestine adenocarcinoma not applicable N/A Guideline Risk Factor Familial adenomatous polyposis results from germline mutations in the APC gene, and is associated with increased risk of developing small bowel adenocarcinoma (NCCN.org). detail...
APC mutant colon adenoma predicted - sensitive TetMYB Preclinical Actionable In a preclinical study, TetMYB treatment resulted in improved median survival compared to control (356 vs 183 days) in APC-driven mouse models of colon adenoma (Gastroenterology, Volume 154, Issue 6, Supplement 1, May 2018, Pages S-1269). detail...
APC mutant colorectal cancer no benefit G-631 Preclinical - Cell line xenograft Actionable In a preclinical study, G-631 inhibited Wnt pathway signaling in colorectal cancer cell line xenograft models harboring an APC mutation, but demonstrated little anti-tumor activity and led to intestinal toxicity (PMID: 26692561). 26692561
APC mutant colorectal cancer sensitive JW74 Preclinical Actionable In a preclinical study, JW74 reduced tumor formation and growth in a mouse model of colorectal cancer harboring an APC mutation (PMID: 21199802). 21199802
APC mutant medulloblastoma not applicable N/A Guideline Prognostic WNT-driven medulloblastomas, characterized by CTNNB1 or APC mutations, are associated with favorable prognosis (NCCN.org). detail...
APC mutant colorectal cancer predicted - sensitive K-756 Preclinical Actionable In a preclinical study, K-756 inhibited Wnt signaling and reduced growth of 2/3 tested APC-mutant colorectal cancer cell lines in culture (PMID: 27196752). 27196752