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Gene | FLT3 |
Variant | Y693C |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | FLT3 Y693C lies within the protein kinase domain of the Flt3 protein (UniProt.org). Y693C has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 32040554, PMID: 35395091), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, May 2022). |
Associated Drug Resistance | Y |
Transcript | NM_004119.2 |
gDNA | chr13:g.28027217T>C |
cDNA | c.2078A>G |
Protein | p.Y693C |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119.2 | chr13:g.28027217T>C | c.2078A>G | p.Y693C | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
FLT3 exon 14 ins FLT3 Y693C | hematologic cancer | resistant | FF-10101 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed hematologic cells expressing FLT3-ITD and FLT3 Y693C were resistant to treatment with FF-10101 in culture (PMID: 35395091). | 35395091 |
FLT3 exon 14 ins FLT3 Y693C | hematologic cancer | resistant | Gilteritinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing FLT3 ITD with FLT3 Y693C demonstrated resistance to treatment with Xospata (gilteritinib) in culture (PMID: 32040554). | 32040554 |
FLT3 exon 14 ins FLT3 Y693C FLT3 D835V | hematologic cancer | resistant | FF-10101 | Preclinical - Cell culture | Actionable | In a preclinical study, transformed hematologic cells expressing FLT3-ITD with FLT3 Y693C and D835V were resistant to treatment with FF-10101 in culture (PMID: 35395091). | 35395091 |
FLT3 exon 14 ins FLT3 Y693C FLT3 D835V | hematologic cancer | resistant | Gilteritinib | Preclinical - Cell culture | Actionable | In a preclinical study, transformed cells expressing FLT3 ITD with FLT3 D835V and FLT3 Y693C were resistant to Xospata (gilteritinib) in culture (PMID: 32040554). | 32040554 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
FLT3 Y693C | unknown | |
FLT3 exon 14 ins FLT3 Y693C | ||
FLT3 exon 14 ins FLT3 Y693C FLT3 D835V |