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|Protein Effect||loss of function - predicted|
|Gene Variant Descriptions||PTEN D109fs results in a change in the amino acid sequence of the Pten protein beginning at aa 109 of 403, likely resulting in premature truncation of the functional protein (UniProt.org). D109fs has not been characterized, however, due to the effects of other truncation mutations downstream of D109 (PMID: 10468583), is predicted to lead to a loss of Pten protein function.|
|Associated Drug Resistance|
|Category Variants Paths||
PTEN mutant PTEN inact mut PTEN D109fs
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|