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Gene TP53
Variant N239_C242del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions TP53 N239_C242del results in the deletion of four amino acids in the DNA-binding domain of the Tp53 protein from amino acids 239 to 242 (UniProt.org). N239_C242del has not been characterized in the scientific literature and therefore, its effect on Tp53 protein function is unknown (PubMed, Feb 2023).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 N239_C242del

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Transcript NM_000546.6
gDNA chr17:g.7674237_7674248del12
cDNA c.716_727del12
Protein p.N239_C242delNSSC
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407262.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7669669_7669680del12 c.715_726del12 p.S239_G242delSKKG RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001407267.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242del RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242del RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242del RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242del RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7673777_7673788del12 c.716_727del12 p.P239_D242delPGRD RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7674237_7674248del12 c.716_727del12 p.N239_C242delNSSC RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References