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Gene RET
Variant D631_L633delinsS
Impact List indel
Protein Effect unknown
Gene Variant Descriptions RET D631_L633delinsS results in a deletion of three amino acids in the extracellular domain of the Ret protein from amino acids 631 to 633, combined with the insertion of one serine (S) at the same site (UniProt.org). D631_L633delinsS has been identified in the scientific literature (PMID: 35616103), but has not been biochemically characterized and therefore, its effect on Ret protein function is unknown (PubMed, Oct 2023).
Associated Drug Resistance
Category Variants Paths

RET mutant RET D631_L633delinsS

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Transcript NM_020975.6
gDNA chr10:g.43114491_43114499delinsAGC
cDNA c.1891_1899delinsAGC
Protein p.D631_L633delinsS
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001406759.1 chr10:g.43114491_43114499delinsAGC c.1891_1899delinsAGC p.D631_L633delinsS RefSeq GRCh38/hg38
NM_020630.7 chr10:g.43114491_43114499delinsAGC c.1891_1899delinsAGC p.D631_L633delinsS RefSeq GRCh38/hg38
NM_001406743.1 chr10:g.43114491_43114499delinsAGC c.1891_1899delinsAGC p.D631_L633delinsS RefSeq GRCh38/hg38
NM_001406760.1 chr10:g.43114491_43114499delinsAGC c.1891_1899delinsAGC p.D631_L633delinsS RefSeq GRCh38/hg38
NM_001406744.1 chr10:g.43114491_43114499delinsAGC c.1891_1899delinsAGC p.D631_L633delinsS RefSeq GRCh38/hg38
NM_020975.5 chr10:g.43114491_43114499delinsAGC c.1891_1899delinsAGC p.D631_L633delinsS RefSeq GRCh38/hg38
NM_020630.5 chr10:g.43114491_43114499delinsAGC c.1891_1899delinsAGC p.D631_L633delinsS RefSeq GRCh38/hg38
NM_020975.6 chr10:g.43114491_43114499delinsAGC c.1891_1899delinsAGC p.D631_L633delinsS RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET D631_L633delinsS thyroid gland medullary carcinoma predicted - sensitive Selpercatinib Case Reports/Case Series Actionable In a Phase I trial, Retevmo (selpercatinib) resulted in stable disease in the target lesions and a partial response in the non-target lesions in a patient with sporadic medullary thyroid cancer harboring RET D631_L633delinsS (PMID: 35616103; NCT03906331). 35616103