Gene Variant Detail

Gene APC
Variant S1356*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions APC S1356* results in a premature truncation of the Apc protein at amino acid 1356 of 2843 (UniProt.org). S1356* has not been characterized, however, due to the effects of an Apc truncation at I1572 (PMID: 10346819), S1356* is predicted to reduce the ability of Apc to regulate beta-catenin.
Associated Drug Resistance

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Transcript NM_000038
gDNA chr5:g.112839661C>A
cDNA c.4067C>A
Protein p.S1356*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000038 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839661C>A c.4067C>A p.S1356* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

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Molecular Profile Protein Effect Treatment Approaches
APC S1356* loss of function - predicted CTNNB1 Inhibitor Tankyrase Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References