Gene Variant Detail

Contact

Missing content? – Request curation!

Request curation for specific Genes, Variants, or PubMed publications.

Have questions, comments, or suggestions? - Let us know!

Email us at : ckbsupport@jax.org

Gene BRAF
Variant K601_W604del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions BRAF K601_W604del results in the deletion of four amino acids in the protein kinase domain of the Braf protein from amino acids 601 to 604 (UniProt.org). K601_W604del has been identified in the scientific literature (PMID: 35598548), but has not been biochemically characterized and therefore, its effect on Braf protein function is unknown (PubMed, May 2023).
Associated Drug Resistance
Category Variants Paths

BRAF mutant BRAF K601_W604del

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Transcript NM_004333.6
gDNA chr7:g.140753324_140753335del12
cDNA c.1802_1813del12
Protein p.K601_W604delKSRW
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001378475.1 chr7:g.140739863_140739874del12 c.1804_1815del12 p.K602_M605delKRLM RefSeq GRCh38/hg38
NM_001354609.1 chr7:g.140753324_140753335del12 c.1802_1813del12 p.K601_W604del RefSeq GRCh38/hg38
NM_001378467.1 chr7:g.140753333_140753344del12 c.1801_1812del12 p.A601_K604delATVK RefSeq GRCh38/hg38
NM_001374244.1 chr7:g.140776914_140776925del12 c.1802_1813del12 p.A601_M604delAQGM RefSeq GRCh38/hg38
NM_001374258.1 chr7:g.140776914_140776925del12 c.1802_1813del12 p.A601_M604delAQGM RefSeq GRCh38/hg38
NM_001354609.2 chr7:g.140753324_140753335del12 c.1802_1813del12 p.K601_W604delKSRW RefSeq GRCh38/hg38
NM_001378471.1 chr7:g.140749358_140749369del12 c.1801_1812del12 p.D601_A604delDVYA RefSeq GRCh38/hg38
XM_047420768.1 chr7:g.140776914_140776925del12 c.1802_1813del12 p.A601_M604delAQGM RefSeq GRCh38/hg38
NM_001378472.1 chr7:g.140749311_140749322del12 c.1801_1812del12 p.Q601_Y604delQLPY RefSeq GRCh38/hg38
NM_001378468.1 chr7:g.140753324_140753335del12 c.1802_1813del12 p.K601_W604delKSRW RefSeq GRCh38/hg38
NM_001378469.1 chr7:g.140749402_140749413del12 c.1801_1812del12 p.E601_R604delEVIR RefSeq GRCh38/hg38
XM_047420767.1 chr7:g.140776914_140776925del12 c.1802_1813del12 p.A601_M604delAQGM RefSeq GRCh38/hg38
XM_017012559.2 chr7:g.140776914_140776925del12 c.1802_1813del12 p.A601_M604delAQGM RefSeq GRCh38/hg38
NM_004333.6 chr7:g.140753324_140753335del12 c.1802_1813del12 p.K601_W604delKSRW RefSeq GRCh38/hg38
NM_004333.5 chr7:g.140753324_140753335del12 c.1802_1813del12 p.K601_W604del RefSeq GRCh38/hg38
NM_001378474.1 chr7:g.140753324_140753335del12 c.1802_1813del12 p.K601_W604delKSRW RefSeq GRCh38/hg38
NM_001378473.1 chr7:g.140749311_140749322del12 c.1801_1812del12 p.Q601_Y604delQLPY RefSeq GRCh38/hg38
XM_047420766.1 chr7:g.140753287_140753298del12 c.1801_1812del12 p.L601_S604delLSGS RefSeq GRCh38/hg38
NM_001378470.1 chr7:g.140749365_140749376del12 c.1801_1812del12 p.F601_D604delFQSD RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References