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Gene PIK3CA
Variant G451_D454del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA G451_D454del results in the deletion of four amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 451 to 454 (UniProt.org). G451_D454del has been identified in sequencing studies (PMID: 26587011), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA G451_D454del

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Transcript NM_006218.4
gDNA chr3:g.179210285_179210296del12
cDNA c.1351_1362del12
Protein p.G451_D454delGLED
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512894.2 chr3:g.179210285_179210296del12 c.1351_1362del12 p.G451_D454del RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210285_179210296del12 c.1351_1362del12 p.G451_D454del RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210285_179210296del12 c.1351_1362del12 p.G451_D454delGLED RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210285_179210296del12 c.1351_1362del12 p.G451_D454del RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210285_179210296del12 c.1351_1362del12 p.G451_D454delGLED RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References