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Gene IDH1
Variant T313I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions IDH1 T313I lies within an NADP-binding region of the Idh1 protein (UniProt.org). T313I confers resistance to an IDH1 inhibitor in the presence of IDH1 R132H, but does not lead to increased production of the oncometabolite 2HG (R(-)-2-hydroxyglutarate), and results in cytokine-independent growth and erythroid differentiation similar to wild-type protein in cell culture (PMID: 36222845), and therefore, is predicted to have no effect on Idh1 protein function.
Associated Drug Resistance Y
Category Variants Paths

IDH1 mutant IDH1 T313I

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Transcript NM_005896.4
gDNA chr2:g.208239916G>A
cDNA c.938C>T
Protein p.T313I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001282387.1 chr2:g.208239916G>A c.938C>T p.T313I RefSeq GRCh38/hg38
NM_005896.3 chr2:g.208239916G>A c.938C>T p.T313I RefSeq GRCh38/hg38
NM_001282386.1 chr2:g.208239916G>A c.938C>T p.T313I RefSeq GRCh38/hg38
NM_005896.4 chr2:g.208239916G>A c.938C>T p.T313I RefSeq GRCh38/hg38
NM_001282386.1 chr2:g.208239916G>A c.938C>T p.T313I RefSeq GRCh38/hg38
NM_001282387.1 chr2:g.208239916G>A c.938C>T p.T313I RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132H IDH1 T313I leukemia resistant Ivosidenib Preclinical - Cell line xenograft Actionable In a preclinical study, Tibsovo (ivosidenib) did not inhibit Idh1 activity and R-2HG production in a leukemia cell line expressing IDH1 R132H and T313I in culture and did not reduce tumor burden in a cell line xenograft model (PMID: 36222845). 36222845
IDH1 R132H IDH1 T313I leukemia predicted - resistant Vorasidenib Preclinical - Biochemical Actionable In a preclinical study, Vorasidenib (AG-881) did not inhibit R-2HG production in a leukemia cell line expressing IDH1 R132H and T313I in culture (PMID: 36222845). 36222845
IDH1 R132H IDH1 T313I leukemia predicted - resistant IDH305 Preclinical - Biochemical Actionable In a preclinical study, IDH305 did not inhibit R-2HG production in a leukemia cell line expressing IDH1 R132H and T313I in culture (PMID: 36222845). 36222845
IDH1 R132H IDH1 T313I leukemia predicted - resistant BAY1436032 Preclinical - Biochemical Actionable In a preclinical study, BAY1436032 did not inhibit R-2HG production in a leukemia cell line expressing IDH1 R132H and T313I in culture (PMID: 36222845). 36222845
IDH1 R132C IDH1 T313I acute myeloid leukemia predicted - resistant Ivosidenib Case Reports/Case Series Actionable In a clinical case study, IDH1 T313I was identified as an acquired mutation in a patient with acute myeloid leukemia harboring IDH1 R132C upon progression on Tibsovo (ivosidenib) (PMID: 36222845). 36222845