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Gene IDH1
Variant A410T
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions IDH1 A410T does not lie within any known functional domains of the Idh1 protein (UniProt.org). A410T does not lead to increased production of the oncometabolite 2HG (R(-)-2-hydroxyglutarate) in cell culture (PMID: 36222845), and therefore, is predicted to have no effect on Idh1 protein function.
Associated Drug Resistance
Category Variants Paths

IDH1 mutant IDH1 A410T

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Transcript NM_005896.4
gDNA chr2:g.208237096C>T
cDNA c.1228G>A
Protein p.A410T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005896.4 chr2:g.208237096C>T c.1228G>A p.A410T RefSeq GRCh38/hg38
NM_001282386.1 chr2:g.208237096C>T c.1228G>A p.A410T RefSeq GRCh38/hg38
NM_001282387.1 chr2:g.208237096C>T c.1228G>A p.A410T RefSeq GRCh38/hg38
NM_001282386.1 chr2:g.208237096C>T c.1228G>A p.A410T RefSeq GRCh38/hg38
NM_001282387.1 chr2:g.208237096C>T c.1228G>A p.A410T RefSeq GRCh38/hg38
NM_005896.3 chr2:g.208237096C>T c.1228G>A p.A410T RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
IDH1 R132H IDH1 A410T leukemia predicted - sensitive Ivosidenib Preclinical - Biochemical Actionable In a preclinical study, Tibsovo (ivosidenib) inhibited enzymatic activity and R-2HG production in a leukemia cell line expressing IDH1 R132H and A410T in culture (PMID: 36222845). 36222845