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Gene PIK3CA
Variant P449_L456del
Impact List deletion
Protein Effect unknown
Gene Variant Descriptions PIK3CA P449_L456del results in the deletion of eight amino acids in the C2 PI3K-type domain of the Pik3ca protein from amino acids 449 to 465 (UniProt.org). P449_L456del has been identified in sequencing studies (PMID: 29316426), but has not been biochemically characterized and therefore, its effect on Pik3ca protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA P449_L456del

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Transcript NM_006218.4
gDNA chr3:g.179210279_179210302del24
cDNA c.1345_1368del24
Protein p.P449_L456delPHGLEDLL
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006713658.5 chr3:g.179210279_179210302del24 c.1345_1368del24 p.P449_L456delPHGLEDLL RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210279_179210302del24 c.1345_1368del24 p.P449_L456delPHGLEDLL RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210279_179210302del24 c.1345_1368del24 p.P449_L456del RefSeq GRCh38/hg38
NM_006218.3 chr3:g.179210279_179210302del24 c.1345_1368del24 p.P449_L456del RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210279_179210302del24 c.1345_1368del24 p.P449_L456del RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References