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|Protein Effect||no effect|
|Gene Variant Descriptions||Wild-type FGFR1 indicates that no mutation has been detected within the FGFR1 gene.|
|Associated Drug Resistance|
|Category Variants Paths|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|FGFR1 wild-type||breast cancer||resistant||Ponatinib||Preclinical||Actionable||In a preclinical study, ER-positive breast cancer cells with wild-type FGFR1 were resistant to growth inhibition by Iclusig (ponatinib) in cell culture (PMID: 22238366).||22238366|
|FGFR1 wild-type||lung cancer||decreased response||AZD4547||Preclinical||Actionable||In a preclinical study, FGFR1 non-amplified lung cancer cell lines demonstrated reduced sensitivity to AZD4547 induced growth inhibition in culture and in xenograft models (PMID: 23082000).||23082000|