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|Protein Effect||no effect|
|Gene Variant Descriptions||NOTCH1 over exp indicates an over expression of the Notch1 protein. However, the mechanism causing the over expression is unspecified.|
|Associated Drug Resistance|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|NOTCH1 over exp||Advanced Solid Tumor||sensitive||Brontictuzumab||Phase I||Actionable||In a Phase I trial, Brontictuzumab (OMP-52M51) treatment resulted in stable disease in 43% (3/7) of advanced solid tumor patients with elevated levels of Notch1 intracellular domain (Mol Cancer Ther 2015;14(12 Suppl 2):Abstract nr C42).||detail...|