Gene Variant Detail

Gene BRAF
Variant G469L
Impact List missense
Protein Effect unknown
Gene Variant Descriptions BRAF G469L is a hotspot mutation lies within the protein kinase domain of the Braf protein (UniProt.org). G469L has been identified in the scientific literature (PMID: 24035431, PMID: 26301799, PMID: 26200454), but has not been biochemically characterized, and therefore, its effect on Braf protein function is unknown (PubMed, Mar 2019).
Associated Drug Resistance

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Transcript NM_004333
gDNA chr7:g.140781602_140781603delCCinsAG
cDNA c.1405_1406delGGinsCT
Protein p.G469L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005250045 chr7:g.140781602_140781603delCCinsAG c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38
NM_004333 chr7:g.140781602_140781603delCCinsAG c.1405_1406delGGinsCT p.G469L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
BRAF G469L unknown MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor LY3009120
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G469L lung adenocarcinoma no benefit Vemurafenib Case Reports/Case Series Actionable In a clinical case study, a lung adenocarcinoma patient harboring BRAF G469L did not respond to Zelboraf (vemurafenib) therapy (PMID: 24035431). 24035431