Gene Variant Detail

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Gene RET
Variant C634F
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions RET C634F lies within the cysteine-rich region of the Ret protein (PMID: 9879991). C634F has not been fully biochemically characterized, but is transforming in cell culture (PMID: 9230192), thus is predicted to confer a gain of function on the Ret protein.
Associated Drug Resistance

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Transcript NM_020975
gDNA chr10:g.43114501G>T
cDNA c.1901G>T
Protein p.C634F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_020975 chr10:g.43114501G>T c.1901G>T p.C634F RefSeq GRCh38/hg38
NM_020630 chr10:g.43114501G>T c.1901G>T p.C634F RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
RET C634F gain of function - predicted RET Inhibitor
Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
RET C634F thyroid gland medullary carcinoma predicted - sensitive Sorafenib Phase II Actionable In a Phase II trial, Nexavar (sorafenib) treatment resulted in stable disease in one patient with medullary thyroid carcinoma harboring RET C634F (PMID: 20368568). 20368568