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Gene FBXW7
Variant G437R
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FBXW7 G437R lies within WD repeat 2 of the Fbxw7 protein (UniProt.org). G437R has been identified in sequencing studies (PMID: 34975100, PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Fbxw7 protein function is unknown (PubMed, Feb 2024).
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 G437R

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Transcript NM_033632.3
gDNA chr4:g.152328317C>T
cDNA c.1309G>A
Protein p.G437R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_047415901.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
NM_033632 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
NM_001349798.2 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_024454123.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_024454121.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_011532085.3 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
NM_018315 chr4:g.152326101C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_047415899.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_017008362 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_047415900.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_011532084 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
NM_018315.4 chr4:g.152326101C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_024454122.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_011532085 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_011532085.2 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
NM_001349798.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_024454124.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
NM_018315.5 chr4:g.152326101C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_011532083 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_011532084.2 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_011532084.3 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_024454123.2 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_047415898.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
NM_033632.3 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38
XM_047415897.1 chr4:g.152328317C>T c.1309G>A p.G437R RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References