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Gene FLT3
Variant A627T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FLT3 A627T lies within the protein kinase domain of the Flt3 protein (UniProt.org). A627T has been identified as a drug resistance mutation (PMID: 15374944, PMID: 17620426), but has not been biochemically characterized and therefore, its effect on Flt3 protein function is unknown (PubMed, Dec 2023).
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon15 FLT3 A627T

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Transcript NM_004119.3
gDNA chr13:g.28033950C>T
cDNA c.1879G>A
Protein p.A627T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28033950C>T c.1879G>A p.A627T RefSeq GRCh38/hg38
NM_004119 chr13:g.28033950C>T c.1879G>A p.A627T RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28033950C>T c.1879G>A p.A627T RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 A627T hematologic cancer predicted - resistant Midostaurin Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing a FLT3-ITD mutation with FLT3 A627T demonstrated moderate resistance to treatment with Rydapt (midostaurin) in culture (PMID: 15374944). 15374944
FLT3 exon 14 ins FLT3 A627T hematologic cancer predicted - resistant Midostaurin Preclinical - Cell culture Actionable In a preclinical study, transformed cells expressing a FLT3-ITD mutation with FLT3 A627T demonstrated resistance to Rydapt (midostaurin) in culture (PMID: 17620426). 17620426
FLT3 exon 14 ins FLT3 A627T hematologic cancer predicted - sensitive PHI-101 Preclinical - Biochemical Actionable In a preclinical study, PHI-101 demonstrated activity against FLT3 A627T in the context of a FLT3-ITD mutation in culture (Cancer Res 2020;80(16 Suppl):Abstract nr 4226). detail...