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Gene FLT3
Variant D835del
Impact List deletion
Protein Effect gain of function
Gene Variant Descriptions FLT3 D835del results in the deletion of an amino acid from the activation loop in the protein kinase domain of the Flt3 protein at amino acid 835 (PMID: 25837374). D835del results in constitutive phosphorylation of Flt3 and activation of Stat5, Erk signaling, leading to transformation of cultured cells (PMID: 15256420).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 D835del

FLT3 mutant FLT3 exon20 FLT3 D835del

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Transcript NM_004119.3
gDNA chr13:g.28018503_28018505delATC
cDNA c.2503_2505delGAT
Protein p.D835delD
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011535015.3 chr13:g.28015681_28015683delCCA c.2503_2505delTGG p.W835delW RefSeq GRCh38/hg38
XM_017020486 chr13:g.28015189_28015191delTTT c.2504_2506delAAA p.K835delK RefSeq GRCh38/hg38
XM_017020486.1 chr13:g.28015189_28015191delTTT c.2504_2506delAAA p.K835delK RefSeq GRCh38/hg38
XM_017020486.2 chr13:g.28015189_28015191delTTT c.2504_2506delAAA p.K835delK RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018503_28018505delATC c.2503_2505delGAT p.D835delD RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28018503_28018505delATC c.2503_2505delGAT p.D835delD RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28015681_28015683delCCA c.2503_2505delTGG p.W835delW RefSeq GRCh38/hg38
NM_004119 chr13:g.28018503_28018505delATC c.2503_2505delGAT p.D835delD RefSeq GRCh38/hg38
XM_011535015 chr13:g.28015681_28015683delCCA c.2503_2505delTGG p.W835delW RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 exon 14 ins FLT3 D835del hematologic cancer sensitive FF-10101 Preclinical - Cell culture Actionable In a preclinical study, FF-10101 treatment inhibited growth of transformed hematologic cells expressing FLT3-ITD and FLT3 D835del in culture (PMID: 35395091). 35395091
FLT3 exon 14 ins FLT3 D835del hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, Xospata (gilteritinib) resulted in reduced cell viability in transformed cells expressing FLT3 ITD with FLT3 D835del in culture (PMID: 32040554). 32040554
FLT3 exon 14 ins FLT3 D835del hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, Xospata (gilteritinib) treatment inhibited growth of transformed hematologic cells expressing FLT3-ITD and FLT3 D835del in culture (PMID: 35395091). 35395091
FLT3 exon 14 ins FLT3 D835del hematologic cancer sensitive Crenolanib Preclinical - Cell culture Actionable In a preclinical study, Crenolanib (CP-868596) treatment inhibited growth of transformed hematologic cells expressing FLT3-ITD and FLT3 D835del in culture (PMID: 35395091). 35395091
FLT3 exon 14 ins FLT3 D835del hematologic cancer resistant Quizartinib Preclinical - Cell culture Actionable In a preclinical study, transformed hematologic cells expressing FLT3-ITD and FLT3 D835del were resistant to treatment with Vanflyta (quizartinib) in culture (PMID: 35395091). 35395091
FLT3 exon 14 ins FLT3 D835del hematologic cancer sensitive Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) treatment inhibited growth of transformed hematologic cells expressing FLT3-ITD and FLT3 D835del in culture (PMID: 35395091). 35395091