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|Gene Variant Descriptions||NOTCH1 F357S lies within the calcium-binding EGF-like domain 9 of the Notch1 protein (UniProt.org). F357S has been identified in sequencing studies (PMID: 27035284, PMID: 24662767), but has not been biochemically characterized and therefore, its effect on Notch1 protein function is unknown (PubMed, Feb 2020).|
|Associated Drug Resistance|
|Transcript||gDNA||cDNA||Protein||Source Database||Genome Build|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|Molecular Profile||Protein Effect||Treatment Approaches|