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Gene FLT3
Variant Y572C
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 Y572C lies within the cytoplasmic domain of the Flt3 protein (UniProt.org). Y572C results in constitutive phosphorylation of Flt3, activation of Erk, Akt and Stat signaling, and is transforming in cell culture (PMID: 18068628, PMID: 30651561).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 Y572C

FLT3 mutant FLT3 act mut FLT3 Y572C

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Transcript NM_004119.3
gDNA chr13:g.28034204T>C
cDNA c.1715A>G
Protein p.Y572C
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011535015 chr13:g.28034147T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28034204T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28034204T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38
XM_011535015.3 chr13:g.28034147T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38
XM_017020488 chr13:g.28015649T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38
NM_004119 chr13:g.28034204T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38
XM_017020488.1 chr13:g.28015649T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38
XM_017020488.2 chr13:g.28015649T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28034147T>C c.1715A>G p.Y572C RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 Y572C Advanced Solid Tumor sensitive Midostaurin Preclinical - Cell culture Actionable In a preclinical study, Rydapt (midostaurin) inhibited FLT3 phosphorylation of ERK1/2 and reduced cell growth in transformed cells expressing FLT3 Y572C in culture (PMID: 18068628). 18068628
FLT3 Y572C hematologic cancer sensitive Crenolanib Preclinical - Cell culture Actionable In a preclinical study, Crenolanib (CP-868596) decreased proliferation of transformed cells expressing FLT3 Y572C in culture (PMID: 30651561). 30651561