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|Protein Effect||gain of function|
|Gene Variant Descriptions||JAK2 act mut indicates that this variant results in a gain of function in the Jak2 protein. However, the specific amino acid change has not been identified.|
|Associated Drug Resistance|
|Molecular Profile||Protein Effect||Treatment Approaches|
|JAK2 act mut||gain of function||JAK Inhibitor (Pan) JAK Inhibitor (Pan) - ATP competitive JAK2 Inhibitor JAK2 Inhibitor - ATP competitive|
|Molecular Profile||Indication/Tumor Type||Response Type||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|