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Gene FLT3
Variant F691L
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FLT3 F691L lies within the protein kinase domain of the Flt3 protein (PMID: 23430109). F691L has been demonstrated to promote secondary drug resistance in the context of FLT3 internal tandem duplication (FLT3-ITD) mutations (PMID: 23430109, PMID: 19318574, PMID: 22504184, PMID: 29187377), but is not transforming in cell culture (PMID: 30651561), and therefore, is predicted to have no effect on Flt3 protein function.
Associated Drug Resistance Y
Category Variants Paths

FLT3 mutant FLT3 exon17 FLT3 F691L

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Transcript NM_004119.3
gDNA chr13:g.28027224A>G
cDNA c.2071T>C
Protein p.F691L
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28027224A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
XM_011535015.3 chr13:g.28027167A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
NM_004119 chr13:g.28027224A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
NM_004119.2 chr13:g.28027224A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
XM_011535015 chr13:g.28027167A>G c.2071T>C p.F691L RefSeq GRCh38/hg38
XM_011535015.2 chr13:g.28027167A>G c.2071T>C p.F691L RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FLT3 F691L no effect - predicted
FLT3 exon 14 ins FLT3 F691L
FLT3 exon 14 ins FLT3 F691L FLT3 R834Q
FLT3 exon 14 ins FLT3 F691L FLT3 D835E
FLT3 exon 14 ins FLT3 F691L FLT3 D835H
FLT3 exon 14 ins FLT3 F691L FLT3 D835N
FLT3 exon 14 ins FLT3 F691L FLT3 D839G
FLT3 exon 14 ins FLT3 F691L FLT3 Y842C
FLT3 exon 14 ins FLT3 F691L FLT3 Y842H
FLT3 exon 14 ins FLT3 F691L FLT3 D835G
FLT3 exon 14 ins FLT3 F691L FLT3 D698N
FLT3 exon 14 ins FLT3 F691L FLT3 D839A
FLT3 exon 14 ins FLT3 F691L FLT3 D839N
FLT3 exon 14 ins FLT3 F691L FLT3 G846R
FLT3 exon 14 ins FLT3 M664I FLT3 F691L
FLT3 exon 14 ins FLT3 N676S FLT3 F691L
FLT3 exon 14 ins FLT3 F691L FLT3 N841K
FLT3 exon 14 ins FLT3 F691L FLT3 R845G
FLT3 exon 14 ins FLT3 F691L FLT3 Y842S
FLT3 exon 14 ins FLT3 F691L FLT3 D835Y
FLT3 F691L FLT3 D835Y
FLT3 exon 14 ins FLT3 F691L FLT3 D835I
FLT3 exon 14 ins FLT3 F691L FLT3 D835V
FLT3 exon 14 ins FLT3 F691L FLT3 D835X