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Gene CDK12
Variant D502Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDK12 D502Y does not lie within any known functional domains of the Cdk12 protein (UniProt.org). D502Y has been identified in sequencing studies (PMID: 23303603, PMID: 22810696), but has not been biochemically characterized and therefore, its effect on Cdk12 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 D502Y

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Transcript NM_016507.4
gDNA chr17:g.39471336G>T
cDNA c.1504G>T
Protein p.D502Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024450801.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524897 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524902 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524895 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024745 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024750 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524906 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524900 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524905 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524893 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024747 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
NM_016507 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524901 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524896 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024746 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024744 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
NM_015083 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524907 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024748 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524898 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524894 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524903 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524899 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524892 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024752 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024751 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_005257458 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38
XM_017024749 chr17:g.39471336G>T c.1504G>T p.D502Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References