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Gene CDK12
Variant P586S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDK12 P586S lies within the proline-rich motif region of the Cdk12 protein (PMID: 22512864). P586S has not been characterized in the scientific literature and therefore, its effect on Cdk12 protein function is unknown (PubMed, Oct 2023).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 P586S

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Transcript NM_016507.4
gDNA chr17:g.39471588C>T
cDNA c.1756C>T
Protein p.P586S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_017024749 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524903 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024751 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524897 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524907 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_005257458 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524900 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024747 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024746 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024752 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524898 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
NM_015083 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524899 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524894 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024750 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524895 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024744 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524892 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524896 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524893 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524905 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524901 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
NM_016507 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524906 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524902 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024748 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38
XM_017024745 chr17:g.39471588C>T c.1756C>T p.P586S RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References