Gene Variant Detail

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Gene CDK12
Variant S192Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions CDK12 S192Y lies within an arginine/serine-rich motif region of the Cdk12 protein (PMID: 22512864). S192Y has not been characterized in the scientific literature and therefore, its effect on Cdk12 protein function is unknown (PubMed, Oct 2023).
Associated Drug Resistance
Category Variants Paths

CDK12 mutant CDK12 S192Y

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Transcript NM_016507.4
gDNA chr17:g.39462646C>A
cDNA c.575C>A
Protein p.S192Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011524892 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524897.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524898.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436263.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_005257456.5 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436268.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524900 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_005257458.4 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436253.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024752.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
NM_016507.4 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436293.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436279.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524893.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
NM_016507 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436255.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524898 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524903 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524901 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436287.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524903.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436290.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436264.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024753 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436288.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436262.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524895.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524894.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024746 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524892.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524895.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524907 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024751 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524899 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024752 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436261.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436273.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524896.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024749.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524902.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524902 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524900.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524906.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436278.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524905.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436266.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_024450801.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436265.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024745 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436291.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524893 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524894.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436289.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524906 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524897 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436276.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024753.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524895 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436256.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436272.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436267.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524907.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524896 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436257.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_005257458 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436270.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
NM_016507.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436277.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524905 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524901.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524906.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024750.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524898.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524894 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436275.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436282.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024744 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024750 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436269.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436284.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436280.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024749 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024753.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024751.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024748 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024748.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524907.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436259.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024747.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436281.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_005257456 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
NM_015083.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436286.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436283.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436285.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_017024747 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436260.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436274.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_005257456.4 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524897.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436258.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524893.3 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_011524899.2 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
NM_015083 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
XM_047436292.1 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38
NM_015083.4 chr17:g.39462646C>A c.575C>A p.S192Y RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References