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Gene FLT3
Variant S585_F594dup
Impact List duplication
Protein Effect gain of function - predicted
Gene Variant Descriptions FLT3 S585_F594dup indicates the insertion of ten duplicate amino acids, serine (S)-585 through phenylalanine (F)-594, in the juxtamembrane domain of the Flt3 protein (PMID: 14759363). S585_F594dup has not been biochemically characterized, but can be predicted to lead to activation of Flt3 based on the effects of other Flt3 internal tandem duplication (ITD) mutations (PMID: 12970773, PMID: 9737679, PMID: 11090077).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 exon 14 ins FLT3 S585_F594dup

FLT3 mutant FLT3 act mut FLT3 exon 14 ins FLT3 S585_F594dup

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Transcript NM_004119.3
gDNA chr13:g.28034137_28034166
cDNA c.1753_1782
Protein p.S585_F594
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.28034137_28034166 c.1753_1782 p.S585_F594 RefSeq GRCh38/hg38
NM_004119 chr13:g.28034136_28034137insAAAGTCTACATAAAAATACTCGTTGTCGCT c.1784_1785insCGACAACGAGTATTTTTATGTAGACTTTAG p.S585_F594dup RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References