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Gene | MSH6 |
Variant | loss |
Impact List | unknown |
Protein Effect | loss of function |
Gene Variant Descriptions | MSH6 loss indicates loss of the MSH6 gene, mRNA, and protein. |
Associated Drug Resistance |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|---|---|---|---|---|---|---|
MSH6 loss | colon cancer | no benefit | KU60648 | Preclinical - Cell culture | Actionable | In a preclinical study, MSH6 deficient colon cancer cells did not respond to treatment with KU60648 in culture (PMID: 28224663). | 28224663 |
MSH6 loss | colon carcinoma | not applicable | N/A | Preclinical | Emerging | Preclinical shRNA mediated-inhibition of PTEN-induced putative kinase 1 (PINK1) in colon carcinoma cells with MSH6 loss resulted in synthetic lethality, suggesting PINK1 may be a promising therapeutic target for MSH6 deficient cancer cells (PMID: 21242281). | 21242281 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
MSH6 loss | loss of function |