Gene Variant Detail

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Gene ATR
Variant I774fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions ATR I774fs results in a change in the amino acid sequence of the Atr protein beginning at aa 774 of 2644, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of all known functional domains (UniProt.org), I774fs is predicted to lead to a loss of Atr protein function.
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR inact mut ATR I774fs

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Transcript NM_001184.3
gDNA chr3:g.(142555898_142555899)
cDNA c.(2320_2319)
Protein p.I774fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512926 chr3:g.(142555898_142555899) c.(2320_2319) p.I774fs RefSeq GRCh38/hg38
NM_001184 chr3:g.(142555898_142555899) c.(2320_2319) p.I774fs RefSeq GRCh38/hg38
NM_001184.3 chr3:g.(142555898_142555899) c.(2320_2319) p.I774fs RefSeq GRCh38/hg38
XM_011512924 chr3:g.(142555898_142555899) c.(2320_2319) p.I774fs RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.(142555898_142555899) c.(2320_2319) p.I774fs RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries