Gene Variant Detail

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Gene ATR
Variant R1183Q
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ATR R1183Q does not lie within any known functional domains of the Atr protein (UniProt.org). R1183Q has been identified in sequencing studies (PMID: 29420467), but has not been biochemically characterized and therefore, its effect on Atr protein function is unknown (PubMed, May 2022).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR R1183Q

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Transcript NM_001184.3
gDNA chr3:g.142540937C>T
cDNA c.3548G>A
Protein p.R1183Q
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001184 chr3:g.142540937C>T c.3548G>A p.R1183Q RefSeq GRCh38/hg38
XM_011512924 chr3:g.142540937C>T c.3548G>A p.R1183Q RefSeq GRCh38/hg38
XM_011512926 chr3:g.142540937C>T c.3548G>A p.R1183Q RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.142540937C>T c.3548G>A p.R1183Q RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142540937C>T c.3548G>A p.R1183Q RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows where any text in any cell matches the filter term
  • Simple literal full or partial string matches
  • Separate multiple filter terms with a spaces, order doesn't matter (a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page, filtering has no impact on query parameters
  • Use quotes to match a longer phrase which contains spaces "mtor c1483f"

Sorting

  • Generally, the default sort order for tables is set to be first column ascending, however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column, be sure to set ascending or descending order for a given column, before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References