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Gene ATR
Variant S601F
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions ATR S601F does not lie within any known functional domains of the Atr protein (UniProt.org). S601F confers a loss of function to the Atr protein as indicated by decreased Chk1 phosphorylation induced by UVB irradiation in culture (PMID: 28273450).
Associated Drug Resistance
Category Variants Paths

ATR mutant ATR inact mut ATR S601F

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Transcript NM_001184.4
gDNA chr3:g.142558707G>A
cDNA c.1802C>T
Protein p.S601F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_011512926 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
XM_011512924.2 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
NM_001184 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
XM_047448364.1 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
XM_047448363.1 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
NM_001184.3 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
XM_011512924.1 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
XM_011512924 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
XM_047448361.1 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
XM_047448360.1 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
XM_047448362.1 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38
NM_001184.4 chr3:g.142558707G>A c.1802C>T p.S601F RefSeq GRCh38/hg38

Filtering

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References