Molecular Profile Detail

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Profile Name NOTCH1 C478F
Gene Variant Detail

NOTCH1 C478F (loss of function - predicted)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
NOTCH1 C478F head and neck squamous cell carcinoma sensitive LGK974 Preclinical Actionable In a preclinical study, LGK974 inhibited growth of head and neck squamous cell carcinoma cells harboring NOTCH1 C478F in culture and xenograft models (PMID: 24277854). 24277854
NOTCH1 C478F head and neck squamous cell carcinoma predicted - sensitive GSK2126458 Preclinical - Cell line xenograft Actionable In a preclinical study, a head and neck squamous cell carcinoma cell line harboring NOTCH1 C478F demonstrated apoptotic activity and reduced colony growth in culture and tumor regression in cell line xenograft models when treated with GSK2126458 (PMID: 30770351). 30770351
NOTCH1 C478F head and neck squamous cell carcinoma predicted - sensitive PQR309 Preclinical - Cell line xenograft Actionable In a preclinical study, head and neck squamous cell carcinoma xenograft models harboring NOTCH1 C478F demonstrated reduced tumor size when treated with PQR309 (bimiralisib) (PMID: 30770351). 30770351
Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries