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|Profile Name||NOTCH1 C478F|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|NOTCH1 C478F||head and neck squamous cell carcinoma||sensitive||LGK974||Preclinical||Actionable||In a preclinical study, LGK974 inhibited growth of head and neck squamous cell carcinoma cells harboring NOTCH1 C478F in culture and xenograft models (PMID: 24277854).||24277854|
|NOTCH1 C478F||head and neck squamous cell carcinoma||predicted - sensitive||GSK2126458||Preclinical - Cell line xenograft||Actionable||In a preclinical study, a head and neck squamous cell carcinoma cell line harboring NOTCH1 C478F demonstrated apoptotic activity and reduced colony growth in culture and tumor regression in cell line xenograft models when treated with GSK2126458 (PMID: 30770351).||30770351|
|NOTCH1 C478F||head and neck squamous cell carcinoma||predicted - sensitive||PQR309||Preclinical - Cell line xenograft||Actionable||In a preclinical study, head and neck squamous cell carcinoma xenograft models harboring NOTCH1 C478F demonstrated reduced tumor size when treated with PQR309 (bimiralisib) (PMID: 30770351).||30770351|
|Clinical Trial||Phase||Therapies||Title||Recruitment Status||Covered Countries||Other Countries|