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|Profile Name||RSPO3 fusion|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|RSPO3 fusion||colorectal cancer||conflicting||GSK3178022||Preclinical - Pdx||Actionable||In a preclinical study, GSK3178022 inhibited Wnt signaling and delayed tumor growth in a patient-derived xenograft (PDX) model of colorectal cancer harboring an RSPO3 translocation, however, failed to inhibit Wnt signaling or tumor growth in a second RSPO3 translocation-positive colorectal cancer PDX model (PMID: 27401612).||27401612|