Molecular Profile Detail

Profile Name AKT1 E17K KRAS wild-type BRAF wild-type
Gene Variant Detail

AKT1 E17K (gain of function)

BRAF wild-type (no effect)

KRAS wild-type (no effect)

Relevant Treatment Approaches

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Molecular Profile Indication/Tumor Type Response Type Relevant Treatment Approaches Therapy Name Approval Status Evidence Type Efficacy Evidence References
AKT1 E17K KRAS wild-type BRAF wild-type colorectal cancer resistant Cetuximab + Irinotecan Clinical Study Actionable In a retrospective study, 100% (2/2) colorectal carcinoma patients harboring an AKT1 E17K mutation and wild-type KRAS/BRAF demonstrated resistance to Erbitux (cetuximab) in combination with Camptosar (irinotecan) (PMID: 25714871). 25714871
Clinical Trial Phase Therapies Title Recruitment Status