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|Profile Name||MDM2 C308Y|
|Gene Variant Detail|
|Relevant Treatment Approaches|
|Molecular Profile||Indication/Tumor Type||Response Type||Relevant Treatment Approaches||Therapy Name||Approval Status||Evidence Type||Efficacy Evidence||References|
|MDM2 C308Y||Advanced Solid Tumor||predicted - resistant||Nutlin-3a||Preclinical - Biochemical||Actionable||In a preclinical study, MDM2 C308Y conferred moderate resistance to Nutlin-3a as demonstrated by decreased restoration of Tp53 activity in reporter assays in culture (PMID: 23653682).||23653682|